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Proceedings Paper

Initial experience with computer aided detection for microcalcification in digital breast tomosynthesis
Author(s): E. F. Harkness; Y. Y. Lim; M. W. Wilson; R. Haq; J. Zhou; C. Tate; A. J. Maxwell; S. M. Astley; F. J. Gilbert
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Paper Abstract

Digital breast tomosynthesis (DBT) addresses limitations of 2-D projection imaging for detection of masses. Microcalcification clusters may be more difficult to appreciate in DBT as individual calcifications within clusters may appear on different slices. This research aims to evaluate the performance of ImageChecker 3D Calc CAD v1.0. Women were recruited as part of the TOMMY trial. From the trial, 169 were included in this study. The DBT images were processed with the computer aided detection (CAD) algorithm. Three consultant radiologists reviewed the images and recorded whether CAD prompts were on or off target. 79/80 (98.8%) malignant cases had a prompt on the area of microcalcification. In these cases, there were 1-15 marks (median 5) with the majority of false prompts (n=326/431) due to benign (68%) and vascular (24%) calcifications. Of 89 normal/benign cases, there were 1-13 prompts (median 3), 27 (30%) had no prompts and the majority of false prompts (n=238) were benign (77%) calcifications. CAD is effective in prompting malignant microcalcification clusters and may overcome the difficulty of detecting clusters in slice images. Although there was a high rate of false prompts, further advances in the software may improve specificity.

Paper Details

Date Published: 20 March 2015
PDF: 6 pages
Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94140L (20 March 2015); doi: 10.1117/12.2081352
Show Author Affiliations
E. F. Harkness, Univ. of Manchester (United Kingdom)
Univ. Hospital of South Manchester (United Kingdom)
Y. Y. Lim, Univ. Hospital of South Manchester (United Kingdom)
M. W. Wilson, Univ. Hospital of South Manchester (United Kingdom)
R. Haq, Univ. Hospital of South Manchester (United Kingdom)
J. Zhou, Univ. Hospital of South Manchester (United Kingdom)
C. Tate, Univ. Hospital of South Manchester (United Kingdom)
A. J. Maxwell, Univ. of Manchester (United Kingdom)
Univ. Hospital of South Manchester (United Kingdom)
S. M. Astley, Univ. of Manchester (United Kingdom)
Univ. Hospital of South Manchester (United Kingdom)
F. J. Gilbert, Univ. of Cambridge (United Kingdom)
Cambridge Hospital NHS Foundation Trust (United Kingdom)


Published in SPIE Proceedings Vol. 9414:
Medical Imaging 2015: Computer-Aided Diagnosis
Lubomir M. Hadjiiski; Georgia D. Tourassi, Editor(s)

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