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Proceedings Paper

A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach
Author(s): Kan Lin; Mads Sylvest Bergholt; Jianfeng Wang; Wei Zheng; Hongzhi Xu; Jian-lin Ren; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang
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Paper Abstract

We report a novel simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman spectroscopy developed for in vivo diagnosis of intestinal metaplasia (IM) in the stomach under wide-field endoscopic imaging. The FP/HW Raman endoscopy technique was performed to differentiate IM from normal tissues with sensitivity of 89% and specificity of 83%. This study shows the great potential of the FP/HW Raman endoscopic technique for early diagnosis of non-neoplastic gastric disease in vivo during routine endoscopic examination.

Paper Details

Date Published: 4 March 2015
PDF: 7 pages
Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93130I (4 March 2015); doi: 10.1117/12.2080896
Show Author Affiliations
Kan Lin, National Univ. of Singapore (Singapore)
Mads Sylvest Bergholt, National Univ. of Singapore (Singapore)
Jianfeng Wang, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Hongzhi Xu, Institute of Digestive Disease, Zhongshan Hospital (China)
Jian-lin Ren, Zhongshan Hospital (China)
Xiamen Univ. (China)
Khek Yu Ho, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Ming Teh, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Khay Guan Yeoh, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 9313:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest; Quan Liu, Editor(s)

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