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Proceedings Paper

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model
Author(s): Joseph T. Acquaviva; Aamr M. Hasanjee; Cody F. Bahavar; Fefian Zhou; Hong Liu; Eric W. Howard; Liz C. Bullen; Ricardo P. Silvy; Wei R. Chen
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Paper Abstract

Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

Paper Details

Date Published: 9 March 2015
PDF: 6 pages
Proc. SPIE 9324, Biophotonics and Immune Responses X, 932415 (9 March 2015); doi: 10.1117/12.2080890
Show Author Affiliations
Joseph T. Acquaviva, Univ. of Central Oklahoma (United States)
Aamr M. Hasanjee, Univ. of Central Oklahoma (United States)
Cody F. Bahavar, Univ. of Central Oklahoma (United States)
Fefian Zhou, Univ. of Central Oklahoma (United States)
Hong Liu, The Univ. of Oklahoma (United States)
Eric W. Howard, The Univ. of Oklahoma Health Sciences Ctr. (United States)
Liz C. Bullen, The Univ. of Oklahoma Health Sciences Ctr. (United States)
Ricardo P. Silvy, Southwest NanoTechnologies Inc. (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 9324:
Biophotonics and Immune Responses X
Wei R. Chen, Editor(s)

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