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Proceedings Paper

Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer
Author(s): Kan Lin; Jianfeng Wang; Mads Sylvest Bergholt; Wei Zheng; Hongzhi Xu; Jian-lin Ren; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang
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Paper Abstract

This work aims to apply a fiber-optic Raman spectroscopy technique for in vivo assessment of adenomatous polyps during clinical colonoscopy. We have developed a fiber-optic Raman endoscopic technique capable of simultaneously acquiring both the fingerprint (FP) (i.e., 800–1800 cm-1) and high-wavenumber (HW) (i.e., 2800–3600 cm-1) Raman spectra for real-time assessment of colorectal carcinogenesis. Simultaneous FP/HW Raman endoscopy provides a diagnostic sensitivity of 90.9% and specificity of 83.3% for differentiating adenoma from hyperplastic polyps, which is superior to either the FP or HW Raman technique alone. This study shows that simultaneous FP/HW Raman spectroscopy has the potential for improving early diagnosis of adenomatous polyps in vivo during colonoscopic examination.

Paper Details

Date Published: 2 March 2015
PDF: 5 pages
Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93040V (2 March 2015); doi: 10.1117/12.2080851
Show Author Affiliations
Kan Lin, National Univ. of Singapore (Singapore)
Jianfeng Wang, National Univ. of Singapore (Singapore)
Mads Sylvest Bergholt, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Hongzhi Xu, Institute of Digestive Disease, Zhongshan Hospital (China)
Jian-lin Ren, Xiamen Univ. (China)
Khek Yu Ho, Yong Loo Lin School of Medicine, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Ming Teh, Yong Loo Lin School of Medicine, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Khay Guan Yeoh, Yong Loo Lin School of Medicine, National Univ. of Singapore (Singapore)
National Univ. Health System (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 9304:
Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II
Melissa J. Suter; Guillermo J. Tearney; Thomas D. Wang; Stephen Lam; Matthew Brenner, Editor(s)

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