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Proceedings Paper

Crystalline organic nanoparticles for diagnosis and PDT
Author(s): R. Steiner; J. Breymayer; Angelika C. Rueck; V. Loschenov; A. Ryabova
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Paper Abstract

Nanoparticles made from aluminum phthalocyanine (AlPc) raw material are non-fluorescent because of fluorescence quenching due to the molecular crystalline structure forming a stack of flat molecular layers. However, when AlPc molecules become detached from the particle, fluorescence occurs. First observations demonstrated the benefit of using aluminum phthalocyanine nanoparticles (nAlPc) for the assessment of the rejection risk of skin autografts in mice by measuring fluorescence intensities of detached AlPc molecules. Skin autografts showing a high fluorescence intensity of AlPc were finally rejected induced by an inflammatory process. In contrast, autografts with normal skin autofluorescence were accepted. This finding stimulated our work to reveal the mechanism of the AlPc fluorescence development from the nanoparticles. This could be used to specifically detect inflammatory processes or tumors and will have the potential of using nAlPc as a new treatment modality for PDT.

Paper Details

Date Published: 2 March 2015
PDF: 7 pages
Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080R (2 March 2015); doi: 10.1117/12.2080773
Show Author Affiliations
R. Steiner, Univ. Ulm (Germany)
J. Breymayer, Univ. Ulm (Germany)
Angelika C. Rueck, Univ. Ulm (Germany)
V. Loschenov, JSC Biospec (Russian Federation)
A. M. Prokhorov General Physics Institute (Russian Federation)
A. Ryabova, A. M. Prokhorov General Physics Institute (Russian Federation)


Published in SPIE Proceedings Vol. 9308:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
David H. Kessel; Tayyaba Hasan, Editor(s)

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