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Proceedings Paper

Acoustic radiation force optical coherence elastography using vibro-acoustography
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Paper Abstract

High-resolution elasticity mapping of tissue biomechanical properties is crucial in early detection of many diseases. We report a method of acoustic radiation force optical coherence elastography (ARF-OCE) based on the methods of vibroacoustography, which uses a dual-ring ultrasonic transducer in order to excite a highly localized 3-D field. The single element transducer introduced previously in our ARF imaging has low depth resolution because the ARF is difficult to discriminate along the entire ultrasound propagation path. The novel dual-ring approach takes advantage of two overlapping acoustic fields and a few-hundred-Hertz difference in the signal frequencies of the two unmodulated confocal ring transducers in order to confine the acoustic stress field within a smaller volume. This frequency difference is the resulting “beating” frequency of the system. The frequency modulation of the transducers has been validated by comparing the dual ring ARF-OCE measurement to that of the single ring using a homogeneous silicone phantom. We have compared and analyzed the phantom resonance frequency to show the feasibility of our approach. We also show phantom images of the ARF-OCE based vibro-acoustography method and map out its acoustic stress region. We concluded that the dual-ring transducer is able to better localize the excitation to a smaller region to induce a focused force, which allows for highly selective excitation of small regions. The beat-frequency elastography method has great potential to achieve high-resolution elastography for ophthalmology and cardiovascular applications.

Paper Details

Date Published: 6 March 2015
PDF: 5 pages
Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270V (6 March 2015); doi: 10.1117/12.2080340
Show Author Affiliations
Yueqiao (Rachel) Qu, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)
Teng Ma, Univ. of Southern California (United States)
Rui Li, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)
Wenjuan Qi, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)
Jiang Zhu, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)
Youmin He, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)
K. Kirk Shung, Univ. of Southern California (United States)
Qifa Zhou, Univ. of Southern California (United States)
Zhongping Chen, Beckman Laser Institute, Univ. of California, Irvine (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 9327:
Optical Elastography and Tissue Biomechanics II
Kirill V. Larin; David D. Sampson, Editor(s)

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