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Proceedings Paper

Small animal imaging platform for quantitative assessment of short-wave infrared-emitting contrast agents
Author(s): Philip Hu; Marco Mingozzi; Laura M. Higgins; Vidya Ganapathy; Margot Zevon; Richard E. Riman; Charles M. Roth; Prabhas V. Moghe; Mark C. Pierce
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Paper Abstract

We report the design, calibration, and testing of a pre-clinical small animal imaging platform for use with short-wave infrared (SWIR) emitting contrast agents. Unlike materials emitting at visible or near-infrared wavelengths, SWIR-emitting agents require detection systems with sensitivity in the 1-2 μm wavelength region, beyond the range of commercially available small animal imagers. We used a collimated 980 nm laser beam to excite rare-earth-doped NaYF4:Er,Yb nanocomposites, as an example of a SWIR emitting material under development for biomedical imaging applications. This beam was raster scanned across the animal, with fluorescence in the 1550 nm wavelength region detected by an InGaAs area camera. Background adjustment and intensity non-uniformity corrections were applied in software. The final SWIR fluorescence image was overlaid onto a standard white-light image for registration of contrast agent uptake with respect to anatomical features.

Paper Details

Date Published: 4 March 2015
PDF: 5 pages
Proc. SPIE 9311, Molecular-Guided Surgery: Molecules, Devices, and Applications, 93110T (4 March 2015); doi: 10.1117/12.2080279
Show Author Affiliations
Philip Hu, Rutgers, The State Univ. of New Jersey (United States)
Marco Mingozzi, Rutgers, The State Univ. of New Jersey (United States)
Laura M. Higgins, Rutgers, The State Univ. of New Jersey (United States)
Vidya Ganapathy, Rutgers, The State Univ. of New Jersey (United States)
Margot Zevon, Rutgers, The State Univ. of New Jersey (United States)
Richard E. Riman, Rutgers, The State Univ. of New Jersey (United States)
Charles M. Roth, Rutgers, The State Univ. of New Jersey (United States)
Prabhas V. Moghe, Rutgers, The State Univ. of New Jersey (United States)
Mark C. Pierce, Rutgers, The State Univ. of New Jersey (United States)


Published in SPIE Proceedings Vol. 9311:
Molecular-Guided Surgery: Molecules, Devices, and Applications
Brian W. Pogue; Sylvain Gioux, Editor(s)

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