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Proceedings Paper

Label-free optical-resolution photoacoustic endomicroscopy in vivo
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Paper Abstract

Intravital microscopy techniques have become increasingly important in biomedical research because they can provide unique microscopic views of various biological or disease developmental processes in situ. Here we present an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system that visualizes internal organs with a much finer resolution than conventional acoustic-resolution photoacoustic endoscopy systems. By combining gradient index (GRIN) lens-based optical focusing and ultrasonic ring transducer-based acoustic focusing, we achieved a transverse resolution as fine as ~10 μm at an optical working distance of 6.5 mm. The OR-PAEM system’s high-resolution intravital imaging capability is demonstrated through animal experiments.

Paper Details

Date Published: 11 March 2015
PDF: 10 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932332 (11 March 2015); doi: 10.1117/12.2080224
Show Author Affiliations
Joon-Mo Yang, Washington Univ. in St. Louis (United States)
Chiye Li, Washington Univ. in St. Louis (United States)
Ruimin Chen, Univ. of Southern California (United States)
Bin Rao, Washington Univ. in St. Louis (United States)
Junjie Yao, Washington Univ. in St. Louis (United States)
Cheng-Hung Yeh, Washington Univ. in St. Louis (United States)
Amos Danielli, Washington Univ. in St. Louis (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Qifa Zhou, Univ. of Southern California (United States)
K. Kirk Shung, Univ. of Southern California (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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