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Proceedings Paper

Real-time treatment light dose guidance of Pleural PDT: an update
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Paper Abstract

The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte- Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.

Paper Details

Date Published: 2 March 2015
PDF: 6 pages
Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 930809 (2 March 2015); doi: 10.1117/12.2080110
Show Author Affiliations
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Rozhin Penjweini, The Univ. of Pennsylvania Health System (United States)
Andreea Dimofte, The Univ. of Pennsylvania Health System (United States)
Jarod C. Finlay, The Univ. of Pennsylvania Health System (United States)
Charles B. Simone, The Univ. of Pennsylvania Health System (United States)
Keith A. Cengel, The Univ. of Pennsylvania Health System (United States)
Joseph Friedberg, Penn Presbyterian Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 9308:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
David H. Kessel; Tayyaba Hasan, Editor(s)

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