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Proceedings Paper

Dendronized iron oxide colloids for imaging the sentinel lymph node
Author(s): J. Jouhannaud; A. Garofalo; D. Felder-Flesch; G. Pourroy
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Paper Abstract

Various methods have been used in medicine for more than one century to explore the lymphatic system. Radioactive colloids (RuS labelled with 99mTc) or/and Vital Blue dye are injected around the primary tumour and detected by means of nuclear probe or visual colour inspection respectively. The simultaneous clinical use of both markers (dye and radionuclide) improves the sensitivity of detection close to 100%. Superparamagnetic iron oxides (SPIOs) are currently receiving much attention as strong T2 weighted magnetic resonance imaging contrast agents that can be potentially used for preoperative localization of sentinel nodes, but also for peroperative detection of sentinel node using hand-held probes. In that context, we present the elaboration of dendronized iron oxide nanoparticles elaborated at the Institute of Physics and Chemistry of Materials of Strasbourg.

Paper Details

Date Published: 12 March 2015
PDF: 6 pages
Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 93380W (12 March 2015); doi: 10.1117/12.2080062
Show Author Affiliations
J. Jouhannaud, CNRS-Univ. de Strasbourg (France)
A. Garofalo, CNRS-Univ. de Strasbourg (France)
D. Felder-Flesch, CNRS-Univ. de Strasbourg (France)
G. Pourroy, CNRS-Univ. de Strasbourg (France)


Published in SPIE Proceedings Vol. 9338:
Colloidal Nanoparticles for Biomedical Applications X
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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