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Proceedings Paper

Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling
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Paper Abstract

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation, which can cause progressive joint damage and disability. Diffuse optical spectroscopy (DOS) and imaging have the potential to become potent monitoring tools for RA. We devised a method that combined time-resolved DOS and tracer kinetics modeling to rapidly and reliably quantify blood flow in the joint. Preliminary results obtained from two animals show that the technique can detect joint inflammation as early as 5 days after onset.

Paper Details

Date Published: 5 March 2015
PDF: 6 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191D (5 March 2015); doi: 10.1117/12.2079811
Show Author Affiliations
Seva Ioussoufovitch, Lawson Health Research Institute (Canada)
Laura B. Morrison, Western Univ. (Canada)
Robarts Research Institute (Canada)
Ting-Yim Lee, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Robarts Research Institute (Canada)
Keith St. Lawrence, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Mamadou Diop, Lawson Health Research Institute (Canada)
Western Univ. (Canada)


Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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