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Proceedings Paper

Disease specific protein corona
Author(s): M. Rahman; M. Mahmoudi
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Paper Abstract

It is now well accepted that upon their entrance into the biological environments, the surface of nanomaterials would be covered by various biomacromolecules (e.g., proteins and lipids). The absorption of these biomolecules, so called ‘protein corona’, onto the surface of (nano)biomaterials confers them a new ‘biological identity’. Although the formation of protein coronas on the surface of nanoparticles has been widely investigated, there are few reports on the effect of various diseases on the biological identity of nanoparticles. As the type of diseases may tremendously changes the composition of the protein source (e.g., human plasma/serum), one can expect that amount and composition of associated proteins in the corona composition may be varied, in disease type manner. Here, we show that corona coated silica and polystyrene nanoparticles (after interaction with in the plasma of the healthy individuals) could induce unfolding of fibrinogen, which promotes release of the inflammatory cytokines. However, no considerable releases of inflammatory cytokines were observed for corona coated graphene sheets. In contrast, the obtained corona coated silica and polystyrene nanoparticles from the hypofibrinogenemia patients could not induce inflammatory cytokine release where graphene sheets do. Therefore, one can expect that disease-specific protein coronas can provide a novel approach for applying nanomedicine to personalized medicine, improving diagnosis and treatment of different diseases tailored to the specific conditions and circumstances.

Paper Details

Date Published: 12 March 2015
PDF: 8 pages
Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 93380V (12 March 2015); doi: 10.1117/12.2079771
Show Author Affiliations
M. Rahman, Tehran Univ. of Medical Sciences (Iran, Islamic Republic of)
Univ. of California Davis (United States)
M. Mahmoudi, Tehran Univ. of Medical Sciences (Iran, Islamic Republic of)
Stanford School of Medicine (United States)


Published in SPIE Proceedings Vol. 9338:
Colloidal Nanoparticles for Biomedical Applications X
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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