Share Email Print
cover

Proceedings Paper

Characterizing infantile hemangiomas with a near-infrared spectroscopic handheld wireless device
Author(s): Christopher J. Fong; Jennifer W. Hoi; Hyun K. Kim; Gerald Behr; Lauren Geller; Nina Antonov; Molly Flexman; Maria Garzon; Andreas H. Hielscher
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Infantile hemangiomas (IH) are common vascular growths that occur in 5-10% of neonates and have the potential to cause disfiguring and even life-threatening complications. Currently, no objective tool exist to monitor either progression or treatment of IH. To address this unmet clinical need, we have developed a handheld wireless device (HWD) that uses diffuse optical spectroscopy for the assessment of IH. The system employs 4 wavelengths (l=780nm, 805nm, 850nm, and 905nm) and 6 source-detector pairs with distances between 0.6 and 20 mm. Placed on the skin surface, backreflection data is obtained and a multispectral evolution algorithm is used to determine total hemoglobin concentration and tissue oxygen saturation. First results of an ongoing pilot study involving 13 patients (average enrollment age = 25 months) suggest that an increase in hypoxic stress over time can lead to the proliferation of IH. Involuting IH lesions showed an increase in tissue oxygen saturation as well as a decrease in total hemoglobin.

Paper Details

Date Published: 5 March 2015
PDF: 6 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 931920 (5 March 2015); doi: 10.1117/12.2079710
Show Author Affiliations
Christopher J. Fong, Columbia Univ. (United States)
Jennifer W. Hoi, Columbia Univ. (United States)
Hyun K. Kim, Columbia Univ. (United States)
Gerald Behr, Columbia Univ. (United States)
Lauren Geller, Columbia Univ. (United States)
Nina Antonov, Columbia Univ. (United States)
Molly Flexman, Columbia Univ. (United States)
Maria Garzon, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)


Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

© SPIE. Terms of Use
Back to Top