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Proceedings Paper

High-speed assessment of liquid viscoelasticity in flow cytometry using nonlinear Brillouin spectroscopy
Author(s): Zhaokai Meng; Georgi I. Petrov; Vladislav V. Yakovlev
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Paper Abstract

Brillouin microspectroscopy is a powerful tool for elasticity-sensitive non-invasive optical imaging and sensing. However, spontaneous Brillouin spectroscopy usually requires long integration time, while its spectral quality is fundamentally limited by the optical setups. In this report, we demonstrated that nonlinear Brillouin spectroscopy based on impulsive stimulated Brillouin spectroscopy is capable of providing the necessary acquisition speed and spectral resolution of elasticity measurements. As a proof-of-principle, we demonstrated potential flow-cytometry applications.

Paper Details

Date Published: 6 March 2015
PDF: 6 pages
Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270P (6 March 2015); doi: 10.1117/12.2079589
Show Author Affiliations
Zhaokai Meng, Texas A&M Univ. (United States)
Georgi I. Petrov, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 9327:
Optical Elastography and Tissue Biomechanics II
Kirill V. Larin; David D. Sampson, Editor(s)

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