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Proceedings Paper

Quantitative assessment of corneal biomechanical properties using optical coherence elastography and a modified Rayleigh Lamb-frequency model
Author(s): Zhaolong Han; Salavat R. Aglyamov; Jiasong Li; Manmohan Singh; Shang Wang; Srilatha Vantipalli; Chen Wu; Chih-hao Liu; Michael D. Twa; Kirill V. Larin
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Paper Abstract

This study reports the application of a modified Rayleigh-Lamb frequency equation (RLFE) to a noncontact optical coherence elastography (OCE) method for quantitative assessment of the biomechanical properties of a porcine cornea. A focused air-pulse induced an elastic wave in the cornea, which was imaged by a phasestabilized optical coherence tomography (OCT) system. From the displacement data acquired by the OCT system, phase velocities of the mechanical wave were extracted by spectral analysis using a fast Fourier transform. Experiments were conducted on 2% agar phantom samples, and the Young’s moduli were assessed by the Rayleigh-Lamb frequency equation, which was validated using uniaxial mechanical compression testing. The Rayleigh-Lamb frequency equation was then applied to OCE data from a normal porcine cornea, in which the fluid-solid effect was considered. The Young’s modulus of the porcine cornea was measured to be ~60 kPa and the shear viscosity was ~0.33 Pa·s. The combination of OCE and RLFE is a promising noninvasive method for the estimation of the biomechanical properties of the cornea in vivo.

Paper Details

Date Published: 20 March 2015
PDF: 5 pages
Proc. SPIE 9307, Ophthalmic Technologies XXV, 930719 (20 March 2015); doi: 10.1117/12.2079542
Show Author Affiliations
Zhaolong Han, Univ. of Houston (United States)
Salavat R. Aglyamov, Univ. of Texas at Austin (United States)
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Shang Wang, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Srilatha Vantipalli, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Chih-hao Liu, Univ. of Houston (United States)
Michael D. Twa, Univ. of Alabama, Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 9307:
Ophthalmic Technologies XXV
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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