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Proceedings Paper

Resonant Raman spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm-1 mode
Author(s): Yan Zhou; Cheng-hui Liu; Lixin Zhou; Ke Zhu; Yulong Liu; Lin Zhang; Susie Boydston-White; Gangge Cheng; Yang Pu; Das Bidyut; Robert R. Alfano
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Paper Abstract

RR spectra of brain normal tissue, gliomas in low grade I and II, and malignant glioma tumors in grade III and IV were measured using a confocal micro Raman spectrometer. This report focus on the relative contents of tryptophan (W) in various grades of brain glioma tumors by the intrinsic molecular resonance Raman (RR) spectroscopy method using the 1588cm-1 of tryptophan mode by 532 nm excitation. The RR spectra of key fingerprints of tryptophan, with a main vibrational mode at 1588cm-1 (W8b), were observed. It was found that tryptophan contribution was accumulated in grade I to IV gliomas and the mode of 1588cm-1 in grade III and IV malignant gliomas were enhanced by resonance.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 931810 (11 March 2015); doi: 10.1117/12.2079458
Show Author Affiliations
Yan Zhou, Air Force General Hospital, PLA (China)
Cheng-hui Liu, The City College of New York (United States)
Lixin Zhou, Beijing Cancer Hospital (China)
Ke Zhu, Institute of Physics, CAS (China)
Yulong Liu, Institute of Physics, CAS (China)
Lin Zhang, The City College of New York (United States)
Susie Boydston-White, The City College of New York (United States)
Borough of Manhattan Community College (United States)
Gangge Cheng, Air Force General Hospital, PLA (China)
Yang Pu, The City College of New York (United States)
Das Bidyut, Fairfield Univ. (United States)
Robert R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 9318:
Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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