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Proceedings Paper

Systematic optimization of MRI guided near infrared diffuse optical spectroscopy in breast
Author(s): Yan Zhao; Michael A. Mastanduno; Shudong Jiang; Fadi El-Ghussein; Junqing Xu; Jiang Gui; Brian W. Pogue; Keith D. Paulsen
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Paper Abstract

A hybrid frequency domain (FD)-continuous wave (CW) MRI/NIRS system was validated in a clinical trial involving patients with at least ACR 4 radiologic findings in Xi’an, China. In this study, MRI guided nonlinear iterative reconstruction of near-infrared spectroscopy (NIRS) images with limited phase data is investigated. In addition, a systematic optimization of the system hardware design has been conducted as well. We are able to get less than 3% variation in tumor contrast to the surrounding normal tissue, by reducing the number of FD detectors from 16 to 6, showing the potential of reducing the FD detectors. Furthermore, a lookup table of the scattering properties has been made by averaging four MRI-identified breast density groups. By using this look-up table for the patient with the noisy phase data, similar AUCs and p-values are achieved for differentiating the malignant from benign patients.

Paper Details

Date Published: 5 March 2015
PDF: 8 pages
Proc. SPIE 9316, Multimodal Biomedical Imaging X, 931605 (5 March 2015); doi: 10.1117/12.2079453
Show Author Affiliations
Yan Zhao, Thayer School of Engineering at Dartmouth (United States)
Michael A. Mastanduno, Thayer School of Engineering at Dartmouth (United States)
Shudong Jiang, Thayer School of Engineering at Dartmouth (United States)
Fadi El-Ghussein, Thayer School of Engineering at Dartmouth (United States)
Junqing Xu, Xijing Hospital (China)
Jiang Gui, Dartmouth College (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 9316:
Multimodal Biomedical Imaging X
Fred S. Azar; Xavier Intes, Editor(s)

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