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Proceedings Paper

Preliminary study for application of optical coherence elastography (OCE) to monitor wound healing processing
Author(s): Guangying Guan; Chunhui Li; Yuting Ling; Fan Zhang; Ana Schor; Zhihong Huang
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Paper Abstract

Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. The classic model is divided into three or four sequential phases: hemostasis; inflammation; proliferation and remodeling. All the procedures are well studied and lots of effort on develop medicine to speed up the procedures or archive scar-less wound healing. Monitoring the microstructure change during the treatment is highly demanded. In this study, a new methodology has been explored aiming to monitor the morphological and mechanical property alteration of wounded tissue. Optical coherence elastography (OCE) equipped which an LDS V201 permanent magnet shaker to provide a vibration signal, has been used for the non-destructive monitoring. In vitro mice skin tissue block from normal ones, Diabetic ones and Diabetic treated with Ile-Gly-Asp-Ser (IGDS) ones after 10 days post wounding have been tested. The structure image is compared to the conventional Histology results, the results is quite promising and OCT system could provide depth information without slicing the sample. Which could be helpful for understanding the recover processing and analysis the different healing phases.

Paper Details

Date Published:
Proc. SPIE 9330, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII, 93300I; doi: 10.1117/12.2079353
Show Author Affiliations
Guangying Guan, Univ. of Dundee (United Kingdom)
Chunhui Li, Univ. of Dundee (United Kingdom)
Yuting Ling, Univ. of Dundee (United Kingdom)
Fan Zhang, Univ. of Dundee (United Kingdom)
Ana Schor, Univ. of Dundee (United Kingdom)
Zhihong Huang, Univ. of Dundee (United Kingdom)

Published in SPIE Proceedings Vol. 9330:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII
Thomas G. Brown; Carol J. Cogswell; Tony Wilson, Editor(s)

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