Share Email Print
cover

Proceedings Paper

Real-time Raman sensing without spectrometer
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Raman spectroscopy has been a powerful tool in various fields of science and technology ranging from analytical chemistry to biomedical imaging. In spite of unique features, Raman spectroscopy has also some limitations. Among them are weak Raman signal compared to strong fluorescence and relatively complicated setup with expensive and bulky spectrometer. In order to increase the sensitivity of Raman technique, many clever attempts have been made and some of them were very successful including CARS, SRS, and so on. However, these still requires expensive and more complicated setup. In this work, we have attempted to build a real-time compact Raman sensor without spectrometer. Conventional spectrometer was replaced with a narrow-band optical filter and alternatively modulated two lasers with slightly different wavelengths. At one laser, Raman signal from a target molecule was transmitted through the optical filter. At the other laser, this signal was blocked by the optical filter and could not be detected by photon detector. The alternative modulation of two lasers will modulate the Raman signal from a target molecule at the same modulation frequency. This modulated weak Raman signal was amplified by a lock-in amplifier. The advantages of this setup include compactness, low cost, real-time monitoring, and so on. We have tested the sensitivity of this setup and we found that it doesn’t have enough sensitivity to detect single molecule-level, but it is still good enough to monitor the change of major chemical composition in the sample.

Paper Details

Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 93180Z (11 March 2015); doi: 10.1117/12.2079278
Show Author Affiliations
Min Ju Kim, Ulsan National Institute of Science and Technology (Korea, Republic of)
Sungho Kim, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)
Timothy K. Yang, Ulsan National Institute of Science and Technology (Korea, Republic of)
Ctr. for Soft and Living Matter, Institute of Basic Science (Korea, Republic of)
Dinesh Kumar, Ulsan National Institute of Science and Technology (Korea, Republic of)
Sung Chul Bae, Ulsan National Institute of Science and Technology (Korea, Republic of)
Institute for Basic Science (Korea, Republic of)


Published in SPIE Proceedings Vol. 9318:
Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

© SPIE. Terms of Use
Back to Top