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Proceedings Paper

Non-invasive submilligram level quantification of in vivo blood components with slitless high-sensitivity spectrometer and noncooled NIR detector
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Paper Abstract

By using a “slit-less” Fourier-transform spectrometer, we demonstrate that cardiac-pulsation amplitude of absorbance can be extracted from 3.5-level absorbance unit (AU) spectra of a human fingertip with a resolution of < 0.0005 AU and a spectral resolution of < several tens of nanometers, even with a low-cost “non-cooled” NIR detector. From the extracted spectrum over 1,000-1,400 nm, the average amounts of pulsating blood components (water, HbO2, and lipids/proteins) in a fingertip are deduced in the sub-milligram order. The results indicate the capacity of the spectrometer for a portable non-invasive blood monitor as well as for a high-end analytic instrument.

Paper Details

Date Published: 4 March 2015
PDF: 6 pages
Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 931314 (4 March 2015); doi: 10.1117/12.2078769
Show Author Affiliations
Ryosuke Kuribayashi, National Institute of Advanced Industrial Science and Technology (Japan)
Hiromitsu Furukawa, National Institute of Advanced Industrial Science and Technology (Japan)


Published in SPIE Proceedings Vol. 9313:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest; Quan Liu, Editor(s)

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