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Proceedings Paper

Quantitative phase imaging of cellular and subcellular structures for non-invasive screening diagnostics of socially significant diseases
Author(s): Irina Vasilenko; Vladislav Metelin; Marat Nasyrov; Vladimir Belyakov; Alexander B. Kuznetsov; Evgeniy Sukhenko
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Paper Abstract

The objective of the present study is to increase the quality of the early diagnosis using cytological differential-diagnostic criteria for reactive changes in the nuclear structures of the immunocompetent cells. The morphofunctional status of living cells were estimated in the real time using new technologic platform of the hardware-software complex for phase cell imaging. The level of functional activity for lymphocyte subpopulations was determined on the base of modification of nuclear structures and decreasing of nuclear phase thickness. The dynamics of nuclear parameters was used as the quantitative measuring for cell activating level and increasing of proliferative potential.

Paper Details

Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9336, Quantitative Phase Imaging, 93362K (11 March 2015); doi: 10.1117/12.2078661
Show Author Affiliations
Irina Vasilenko, Maimonides State Classical Academy (Russian Federation)
Vladislav Metelin, Maimonides State Classical Academy (Russian Federation)
Marat Nasyrov, Russian Medical Academy of Postgraduate Education (Russian Federation)
Vladimir Belyakov, N.I. Pirogov Russian National Research Medical Univ. (Russian Federation)
Alexander B. Kuznetsov, Pirogov Russian National Research Medical Univ. (Russian Federation)
Evgeniy Sukhenko, N.I. Pirogov Russian National Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9336:
Quantitative Phase Imaging
Gabriel Popescu; YongKeun Park, Editor(s)

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