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Proceedings Paper

Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures
Author(s): Jiasong Li; Manmohan Singh; Srilatha Vantipalli; Zhaolong Han; Chih-Hao Liu; Michael D. Twa; Kirill V. Larin
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Paper Abstract

In this study we demonstrate the use of phase-stabilized swept-source optical coherence elastography (PhS-SSOCE) to assess the biomechanical properties of porcine corneas before and after collagen cross-linking (CXL) at different intraocular pressures by measuring the velocity of an air-pulse induced elastic wave and recovery process rate of an air-pulse induced deformation. Young’s moduli were estimated by two different methods: the shear wave equation and a newly developed elasticity reconstruction model. The results show that the corneas became stiffer after the CXL treatment, as evidenced by the increased elastic wave velocity and recovery process rate and greater Young’s modulus. This non-contact and noninvasive measurement technique utilizes minimal force for excitation (deformation less than 10 μm in amplitude) of the tissue. Thus, it can be potentially used to study the biomechanical properties of ocular and other delicate tissues.

Paper Details

Date Published: 6 March 2015
PDF: 6 pages
Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270Z (6 March 2015); doi: 10.1117/12.2078328
Show Author Affiliations
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Srilatha Vantipalli, Univ. of Houston (United States)
Zhaolong Han, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Michael D. Twa, Univ. of Alabama at Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 9327:
Optical Elastography and Tissue Biomechanics II
Kirill V. Larin; David D. Sampson, Editor(s)

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