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Proceedings Paper

Histology in vivo: chemical contrast combined with clinical multimodal multiphoton tomography
Author(s): Martin Weinigel; Hans Georg Breunig; Karsten Koenig
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Paper Abstract

Label-free multiphoton tomography based on two-photon autofluorescence, fluorescence lifetime, and second harmonic generation imaging can be supplemented by coherent anti-Stokes Raman scattering. We present a compact, mobile and flexible clinical tomograph equipped with a novel detector design with multiple miniaturized detectors for individual acquisition of all four contrast mechanisms. Imaging of endogenous fluorophores, SHG-active collagen as well as nonfluorescent lipids in human skin in vivo is possible with this clinical tomograph paving the way towards in vivo histology.

Paper Details

Date Published: 5 March 2015
PDF: 4 pages
Proc. SPIE 9329, Multiphoton Microscopy in the Biomedical Sciences XV, 93291N (5 March 2015); doi: 10.1117/12.2078307
Show Author Affiliations
Martin Weinigel, JenLab GmbH (Germany)
Univ. of Technology, Ilmenau (Germany)
Hans Georg Breunig, JenLab GmbH (Germany)
Univ. des Saarlandes (Germany)
Karsten Koenig, Univ. des Saarlandes (Germany)
JenLab GmbH (Germany)


Published in SPIE Proceedings Vol. 9329:
Multiphoton Microscopy in the Biomedical Sciences XV
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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