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Proceedings Paper

Bone assessment via thermal photoacoustic measurements
Author(s): Ting Feng; Kenneth M. Kozloff; Yi-Sing Hsiao; Chao Tian; Joseph Perosky; Sidan Du; Jie Yuan; Cheri X. Deng; Xueding Wang
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Paper Abstract

The feasibility of an innovative biomedical diagnostic technique, thermal photoacoustic (TPA) measurement, for nonionizing and non-invasive assessment of bone health is investigated. Unlike conventional photoacoustic PA methods which are mostly focused on the measurement of absolute signal intensity, TPA targets the change in PA signal intensity as a function of the sample temperature, i.e. the temperature dependent Grueneisen parameter which is closely relevant to the chemical and molecular properties in the sample. Based on the differentiation measurement, the results from TPA technique is less susceptible to the variations associated with sample and system, and could be quantified with improved accurately. Due to the fact that the PA signal intensity from organic components such as blood changes faster than that from non-organic mineral under the same modulation of temperature, TPA measurement is able to objectively evaluate bone mineral density (BMD) and its loss as a result of osteoporosis. In an experiment on well established rat models of bone loss and preservation, PA measurements of rat tibia bones were conducted over a temperature range from 370 C to 440 C. The slope of PA signal intensity verses temperature was quantified for each specimen. The comparison among three groups of specimens with different BMD shows that bones with lower BMD have higher slopes, demonstrating the potential of the proposed TPA technique in future clinical management of osteoporosis.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231D (11 March 2015); doi: 10.1117/12.2078228
Show Author Affiliations
Ting Feng, Nanjing Univ. (China)
Univ. of Michigan (United States)
Kenneth M. Kozloff, Univ. of Michigan (United States)
Yi-Sing Hsiao, Univ. of Michigan (United States)
Chao Tian, Univ. of Michigan (United States)
Joseph Perosky, Univ. of Michigan (United States)
Sidan Du, Nanjing Univ. (China)
Jie Yuan, Nanjing Univ. (China)
Cheri X. Deng, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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