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Proceedings Paper

Photoacoustic biopsy: a feasibility study
Author(s): Guan Xu; Scott A. Tomlins; Javed Siddiqui; Mandy Davis; Lakshmi P. Kunju; John T. Wei; Xueding Wang
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Paper Abstract

Photoacoustic (PA) measurements encode the information associated with both physical microstructures and chemical contents in biological tissues. A two-dimensional physio-chemical spectrogram (PCS) can be formulated by combining the power spectra of PA signals acquired at a series of optical wavelengths. The analysis of PCS, or namely PA physio-chemical analysis (PAPCA), enables the quantification of the concentrations and the spatial distributions of a variety of chemical components in the tissue. The chemical components and their distribution are the two major features observed in the biopsy procedures which have been regarded as the gold standard of the diagnosis of many diseases. Taking non-alcoholic fatty liver disease and prostate cancer for example, this study investigates the feasibility of PAPCA in characterizing the histopathological changes in the diseased conditions in biological tissue. A catheter based setup facilitating measurement in deep tissues was also proposed and tested.

Paper Details

Date Published: 5 March 2015
PDF: 7 pages
Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 931806 (5 March 2015); doi: 10.1117/12.2078068
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Scott A. Tomlins, Univ. of Michigan Medical School (United States)
Javed Siddiqui, Univ. of Michigan Medical School (United States)
Mandy Davis, Univ. of Michigan Medical School (United States)
Lakshmi P. Kunju, Univ. of Michigan Medical School (United States)
John T. Wei, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 9318:
Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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