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Proceedings Paper

Evaluation of Gleason scores by photoacoustic spectral analysis
Author(s): Guan Xu; Scott A. Tomlins; Javed Siddiqui; Mandy Davis; Lakshmi P. Kunju; John T. Wei; Xueding Wang
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Paper Abstract

Ultrasound (US) guided biopsy is the standard procedure for evaluating the presence of prostate cancer (PCa). The biopsied tissues are evaluated by a Gleason scoring system which quantifies the severity of prostate cancer based on the clustering patterns of the cancer cells. The clustering patterns can be visualized by staining the cancer cells with optical contrast enhancing nanoparticles (NPs). This study investigates the feasibility of evaluating the NP stained Gleason patterns using photoacoustic spectrum analysis (PASA), aiming toward achieving minimally invasive prostate biopsy. The experiment on H&E stained human prostate tissue slices demonstrates that this approach is capable of identifying and potentially grading PCa.

Paper Details

Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231S (11 March 2015); doi: 10.1117/12.2078065
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Scott A. Tomlins, Univ. of Michigan Medical School (United States)
Javed Siddiqui, Univ. of Michigan Medical School (United States)
Mandy Davis, Univ. of Michigan Medical School (United States)
Lakshmi P. Kunju, Univ. of Michigan Medical School (United States)
John T. Wei, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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