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Proceedings Paper

Photoacoustic physio-chemical analysis and its implementation in deep tissue with a catheter setup
Author(s): Guan Xu; Zhou-xian Meng; Jian-die D. Lin; Qian Cheng; Xueding Wang
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Paper Abstract

Photoacoustic (PA) measurements encode the information associated with both physical microstructures and chemical contents in biological tissues. A two-dimensional physio-chemical spectrogram (PCS) can be formulated by combining the power spectra of PA signals acquired at a series of optical wavelengths. The analysis of PCS, or namely PA physio-chemical analysis (PAPCA), enables the quantification of the relative concentrations and the spatial distributions of a variety of chemical components in the tissue. This study validated the feasibility of PAPCA in characterizing liver conditions during the progression of non-alcoholic fatty liver disease. A catheter based setup facilitating measurement in deep tissues was also tested.

Paper Details

Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93234F (11 March 2015); doi: 10.1117/12.2078063
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Zhou-xian Meng, Univ. of Michigan Medical School (United States)
Jian-die D. Lin, Univ. of Michigan Medical School (United States)
Qian Cheng, Univ. of Michigan Medical School (United States)
Tongji Univ. (China)
Xueding Wang, Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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