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Proceedings Paper

Boundary conditions independent diffuse correlation spectroscopy
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Paper Abstract

Diffuse correlation spectroscopy (DCS) can measure perfusion changes in deep tissue. However, DCS requires solving the diffusion equation with the proper boundary conditions which can be very difficult and even impossible in many cases. We present a DCS approach that is independent of boundary conditions. The approach is based on measuring the probability distribution function (PDF) of the photons’ pathlengths by deconvolving the temporal point-spread function and the instrument-response function obtained from time-resolved measurements. The recovered PDF was then used to fit the field correlation function to extract perfusion changes. This approach can be applied to any geometry and is valid for diffusive, single-scattering and multiple-scattering, but non-diffusive media.

Paper Details

Date Published: 12 March 2015
PDF: 5 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 931917 (12 March 2015); doi: 10.1117/12.2077799
Show Author Affiliations
Mamadou Diop, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Keith St. Lawrence, Lawson Health Research Institute (Canada)
Western Univ. (Canada)


Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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