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Proceedings Paper

Advanced laser systems for photoacoustic imaging
Author(s): Marc Klosner; Ashwin Sampathkumar; Gary Chan; Chunbai Wu; Daniel Gross; Donald F. Heller
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Paper Abstract

We describe the ongoing development of laser systems for advanced photoacoustic imaging (PAI). We discuss the characteristics of these laser systems and their particular benefits for soft tissue imaging and next-generation breast cancer diagnostics. We provide an overview of laser performance and compare this with other laser systems that have been used for early-stage development of PAI. These advanced systems feature higher pulse energy output at clinically relevant repetition rates, as well as a novel wavelength-cycling output pulse format. Wavelength cycling provides pulse sequences for which the output repeatedly alternates between two wavelengths that provide differential imaging. This capability improves co-registration of captured differential images. We present imaging results of phantoms obtained with a commercial ultrasound detector system and a wavelength-cycling laser source providing ~500 mJ/pulse at 755 and 797 nm, operating at 25 Hz. The results include photoacoustic images and corresponding pulse-echo data from a tissue mimicking phantom containing inclusions, simulating tumors in the breast. We discuss the application of these systems to the contrast-enhanced detection of various tissue types and tumors.

Paper Details

Date Published: 11 March 2015
PDF: 18 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932349 (11 March 2015); doi: 10.1117/12.2077780
Show Author Affiliations
Marc Klosner, Light Age, Inc. (United States)
Ashwin Sampathkumar, Riverside Research (United States)
Gary Chan, Light Age, Inc. (United States)
Chunbai Wu, Light Age, Inc. (United States)
Daniel Gross, Riverside Research (United States)
Donald F. Heller, Light Age, Inc. (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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