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Proceedings Paper

Detecting inflammation and fibrosis in bowel wall with photoacoustic imaging in a Crohn's disease animal model
Author(s): Guan Xu; Laura A. Johnson; Jack Hu; Jonathan R. Dillman; Peter D. R. Higgins; Xueding Wang
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Paper Abstract

Crohn’s disease (CD) is an autoimmune disease affecting 700,000 people in the United States. This condition may cause obstructing intestinal narrowings (strictures) due to inflammation, fibrosis (deposition of collagen), or a combination of both. Utilizing the unique strong optical absorption of hemoglobin at 532 nm and collagen at 1370 nm, this study investigated the feasibility of non-invasively characterizing intestinal strictures using photoacoustic imaging (PAI). Three normal controls, ten pure inflammation and 9 inflammation plus fibrosis rat bowel wall samples were imaged. Statistical analysis of the PA measurements has shown the capability of discriminating the purely inflammatory from mixed inflammatory and fibrotic strictures.

Paper Details

Date Published: 11 March 2015
PDF: 5 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932347 (11 March 2015); doi: 10.1117/12.2077634
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Laura A. Johnson, Univ. of Michigan Medical School (United States)
Jack Hu, Univ. of Michigan Medical School (United States)
Jonathan R. Dillman, Univ. of Michigan Medical School (United States)
Peter D. R. Higgins, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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