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Proceedings Paper

The combination design for open and endoscopic surgery using fluorescence molecular imaging technology
Author(s): Yamin Mao; Shixin Jiang; Jinzuo Ye; Yu An; Xin Yang; Chongwei Chi; Jie Tian
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Paper Abstract

For clinical surgery, it is still a challenge to objectively determine tumor margins during surgery. With the development of medical imaging technology, fluorescence molecular imaging (FMI) method can provide real-time intraoperative tumor margin information. Furthermore, surgical navigation system based on FMI technology plays an important role for the aid of surgeons’ precise tumor margin decision. However, detection depth is the most limitation exists in the FMI technique and the method convenient for either macro superficial detection or micro deep tissue detection is needed. In this study, we combined advantages of both open surgery and endoscopic imaging systems with FMI technology. Indocyanine green (ICG) experiments were performed to confirm the feasibility of fluorescence detection in our system. Then, the ICG signal was photographed in the detection area with our system. When the system connected with endoscope lens, the minimum quantity of ICG detected by our system was 0.195 ug. For aspect of C mount lens, the sensitivity of ICG detection with our system was 0.195ug. Our experiments results proved that it was feasible to detect fluorescence images with this combination method. Our system shows great potential in the clinical applications of precise dissection of various tumors

Paper Details

Date Published: 4 March 2015
PDF: 7 pages
Proc. SPIE 9311, Molecular-Guided Surgery: Molecules, Devices, and Applications, 93110J (4 March 2015); doi: 10.1117/12.2077119
Show Author Affiliations
Yamin Mao, Key Lab. of Molecular Imaging (China)
Shixin Jiang, Beijing Jiaotong Univ. (China)
Jinzuo Ye, Key Lab. of Molecular Imaging (China)
Yu An, Beijing Jiaotong Univ. (China)
Xin Yang, Key Lab. of Molecular Imaging (China)
Chongwei Chi, Key Lab. of Molecular Imaging (China)
Jie Tian, Key Lab. of Molecular Imaging (China)


Published in SPIE Proceedings Vol. 9311:
Molecular-Guided Surgery: Molecules, Devices, and Applications
Brian W. Pogue; Sylvain Gioux, Editor(s)

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