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Proceedings Paper

Simulation and measurement of transcranial near infrared light penetration
Author(s): Lan Yue; Manuel Monge; Mehmet H. Ozgur; Kevin Murphy; Stan Louie; Carol A. Miller; Azita Emami; Mark S. Humayun
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Paper Abstract

We are studying the transmission of LED array-emitted near-infrared (NIR) light through human tissues. Herein, we simulated and measured transcranial NIR penetration in highly scattering human head tissues. Using finite element analysis, we simulated photon diffusion in a multilayered 3D human head model that consists of scalp, skull, cerebral spinal fluid, gray matter and white matter. The optical properties of each layer, namely scattering and absorption coefficient, correspond to the 850 nm NIR light. The geometry of the model is minimally modified from the IEEE standard and the multiple LED emitters in an array were evenly distributed on the scalp. Our results show that photon distribution produced by the array exhibits little variation at similar brain depth, suggesting that due to strong scattering effects of the tissues, discrete spatial arrangements of LED emitters in an array has the potential to create a quasi-radially symmetrical illumination field. Measurements on cadaveric human head tissues excised from occipital, parietal, frontal and temporal regions show that illumination with an 850 nm LED emitter rendered a photon flux that closely follows simulation results. In addition, prolonged illumination of LED emitted NIR showed minimal thermal effects on the brain.

Paper Details

Date Published: 5 March 2015
PDF: 6 pages
Proc. SPIE 9321, Optical Interactions with Tissue and Cells XXVI, 93210S (5 March 2015); doi: 10.1117/12.2077019
Show Author Affiliations
Lan Yue, Univ. of Southern California (United States)
Manuel Monge, California Institute of Technology (United States)
Mehmet H. Ozgur, Providence Holy Cross Medical Ctr. (United States)
Kevin Murphy, Univ. of Southern California (United States)
Stan Louie, The Univ. of Southern California (United States)
Carol A. Miller, Univ. of Southern California (United States)
Azita Emami, California Institute of Technology (United States)
Mark S. Humayun, Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 9321:
Optical Interactions with Tissue and Cells XXVI
E. Duco Jansen, Editor(s)

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