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Proceedings Paper

FNIRS-based evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy
Author(s): Jianwei Cao; Bilal Khan; Nathan Hervey; Fenghua Tian; Mauricio R. Delgado; Nancy J. Clegg; Linsley Smith; Heather Roberts; Kirsten Tulchin-Francis; Angela Shierk; Laura Shagman; Duncan MacFarlane; Hanli Liu; George Alexandrakis
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Paper Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 ± 2.1 years old) with hemiplegic cerebral palsy (CP) was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger tapping task were quantified before, immediately after, and six months after CIMT. Five age-matched healthy children (9.8 ± 1.3 years old) were also imaged at the same time points to provide comparative activation metrics for normal controls. In children with CP the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted six months later. In contrast to this longer term improvement in localized activation response, the laterality index that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed six months later.

Paper Details

Date Published: 10 March 2015
PDF: 7 pages
Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050N (10 March 2015); doi: 10.1117/12.2076995
Show Author Affiliations
Jianwei Cao, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Bilal Khan, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Nathan Hervey, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Mauricio R. Delgado, Texas Scottish Rite Hospital for Children (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Nancy J. Clegg, Texas Scottish Rite Hospital for Children (United States)
Linsley Smith, Texas Scottish Rite Hospital for Children (United States)
Heather Roberts, Texas Scottish Rite Hospital for Children (United States)
Kirsten Tulchin-Francis, Texas Scottish Rite Hospital for Children (United States)
Angela Shierk, Texas Scottish Rite Hospital for Children (United States)
Laura Shagman, The Univ. of Texas at Dallas (United States)
Duncan MacFarlane, The Univ. of Texas at Dallas (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
George Alexandrakis, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)


Published in SPIE Proceedings Vol. 9305:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Henry Hirschberg; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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