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Proceedings Paper

In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements, or implants
Author(s): Andreas M. Schmocker; Azadeh Khoushabi; Pierre-Etienne Bourban; Constantin Schizas; Dominique Pioletti; Christophe Moser
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Paper Abstract

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler simply by illumination. Traditionally, photopolymerization has been used mainly in dentistry. Over the last decade advances in material development including a wide range of biocompatible gel- and cement-systems open up a new avenue for in-situ photopolymerization.

However, at the device level, surgical endoscopic probes are required. We present a miniaturized light probe where a photoactive material can be 1) mixed, pressurized and injected 2) photopolymerized or photoactivated and 3) monitored during the chemical reaction. The device enables surgeries to be conducted through a hole smaller than 1 mm in diameter.

Beside basic injection mechanics, the tool consists of an optical fiber guiding the light required for photopolymerization and for chemical analysis. Combining photorheology and fluorescence spectroscopy, the current state of the photopolymerization is inferred and monitored in real time. Biocompatible and highly tuneable Poly-Ethylene-Glycol (PEG) hydrogels were used as the injection material.

The device was tested on a model for intervertebral disc replacement. Gels were successfully implanted into a bovine caudal model and mechanically tested in-vitro during two weeks. The photopolymerized gel was evaluated at the tissue level (adherence and mechanical properties of the implant), at the cellular level (biocompatibility and cytotoxicity) and ergonomic level (sterilization procedure and feasibility study).

This paper covers the monitoring aspect of the device.

Paper Details

Date Published: 4 March 2015
PDF: 6 pages
Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93130C (4 March 2015); doi: 10.1117/12.2076680
Show Author Affiliations
Andreas M. Schmocker, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Azadeh Khoushabi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Pierre-Etienne Bourban, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Constantin Schizas, Ctr. Hospitalier Univ. Vaudois (Switzerland)
Dominique Pioletti, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christophe Moser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 9313:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest; Quan Liu, Editor(s)

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