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Proceedings Paper

Characterization of hemodynamics and oxygenation in the renal cortex of rats
Author(s): Dirk Grosenick; Heidrun Wabnitz; Rainer Macdonald; Thoralf Niendorf; Kathleen Cantow; Bert Flemming; Karen Arakelyan; Erdmann Seeliger
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Paper Abstract

We have performed a pre-clinical study on 13 rats to investigate the potential of near-infrared spectroscopy for quantification of hemoglobin concentration and oxygen saturation of hemoglobin in the renal cortex of small animals. These measurements were combined with laser-Doppler fluxmetry and a fluorescence quenching technique for quantification of tissue oxygen tension. Hemoglobin concentration and oxygen saturation were determined from experimental data by a Monte Carlo model. The methods were applied to investigate and compare temporal changes during several types of interventions such as arterial and venous occlusions, as well as hyperoxia, hypoxia and hypercapnia induced by different mixtures of the inspired gas.

Paper Details

Date Published: 5 March 2015
PDF: 5 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191C (5 March 2015); doi: 10.1117/12.2076148
Show Author Affiliations
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Thoralf Niendorf, Max-Delbrück-Ctr. für Molekulare Medizin Berlin-Buch (Germany)
Kathleen Cantow, Charité Universitätsmedizin Berlin (Germany)
Bert Flemming, Charité Universitätsmedizin Berlin (Germany)
Karen Arakelyan, Max-Delbrück-Ctr. für Molekulare Medizin Berlin-Buch (Germany)
Charité Universitätsmedizin Berlin (Germany)
Erdmann Seeliger, Charité Universitätsmedizin Berlin (Germany)


Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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