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Proceedings Paper

Photoacoustic tomography guided diffuse optical tomography for small-animal model
Author(s): Yihan Wang; Feng Gao; Wenbo Wan; Yan Zhang; Jiao Li
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Paper Abstract

Diffuse optical tomography (DOT) is a biomedical imaging technology for noninvasive visualization of spatial variation about the optical properties of tissue, which can be applied to in vivo small-animal disease model. However, traditional DOT suffers low spatial resolution due to tissue scattering. To overcome this intrinsic shortcoming, multi-modal approaches that incorporate DOT with other imaging techniques have been intensively investigated, where a priori information provided by the other modalities is normally used to reasonably regularize the inverse problem of DOT. Nevertheless, these approaches usually consider the anatomical structure, which is different from the optical structure. Photoacoustic tomography (PAT) is an emerging imaging modality that is particularly useful for visualizing lightabsorbing structures embedded in soft tissue with higher spatial resolution compared with pure optical imaging. Thus, we present a PAT-guided DOT approach, to obtain the location a priori information of optical structure provided by PAT first, and then guide DOT to reconstruct the optical parameters quantitatively. The results of reconstruction of phantom experiments demonstrate that both quantification and spatial resolution of DOT could be highly improved by the regularization of feasible-region information provided by PAT.

Paper Details

Date Published: 5 March 2015
PDF: 7 pages
Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160P (5 March 2015); doi: 10.1117/12.2075890
Show Author Affiliations
Yihan Wang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Wenbo Wan, Tianjin Univ. (China)
Yan Zhang, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)

Published in SPIE Proceedings Vol. 9316:
Multimodal Biomedical Imaging X
Fred S. Azar; Xavier Intes, Editor(s)

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