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Proceedings Paper

Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods
Author(s): Chunhui Li; Guangying Guan; Zhihong Huang; Ruikang K. Wang; Ghulam Nabi
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Paper Abstract

By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ~0mm to ~4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

Paper Details

Date Published: 5 March 2015
PDF: 9 pages
Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220O (5 March 2015); doi: 10.1117/12.2075666
Show Author Affiliations
Chunhui Li, Univ. of Dundee (United Kingdom)
Guangying Guan, Univ. of Washington (United States)
Univ. of Dundee (United Kingdom)
Zhihong Huang, Univ. of Dundee (United Kingdom)
Ruikang K. Wang, Univ. of Washington (United States)
Ghulam Nabi, Univ. of Dundee (United Kingdom)

Published in SPIE Proceedings Vol. 9322:
Dynamics and Fluctuations in Biomedical Photonics XII
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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