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Proceedings Paper

In vivo experimental validation for a featured-data time-domain diffuse fluorescence tomography based on the radiative transfer equation
Author(s): Yan Zhang; Limin Zhang; Meng Jin; Huijuan Zhao; Feng Gao; Jiao Li
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Paper Abstract

In diffuse florescence tomography (DFT), the radiative transfer equation (RTE) and its P1 approximation, i.e. the diffuse equation (DE), have been used as the forward models. Since the assumptions of the diffusion approximation are not valid in particular regions of biological tissue which are close to the collimated light sources and boundaries, not scattering dominated or having void-like sub-domains, the RTE-based DFT methodology has become a focus of investigation. Therefore, we present a RTE-based featured-data scheme for time-domain DFT, which combines the discrete solidangle- element method and the finite element method to obtain numerical solutions of the Laplace-transformed 2D timedomain RTE, with the natural boundary condition and collimating light source model. The scheme is validated using the measurement data from phantom and in-vivo small-animal experiments compared to the DE-based scheme.

Paper Details

Date Published: 5 March 2015
PDF: 8 pages
Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191S (5 March 2015); doi: 10.1117/12.2075647
Show Author Affiliations
Yan Zhang, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Meng Jin, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Feng Gao, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Jiao Li, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)


Published in SPIE Proceedings Vol. 9319:
Optical Tomography and Spectroscopy of Tissue XI
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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