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Proceedings Paper

Ideal flushing agents for integrated optical acoustic imaging systems
Author(s): Jiawen Li; Hataka Minami; Earl Steward; Teng Ma; Dilbahar Mohar; Claire Robertson; K. Kirk Shung; Qifa Zhou; Pranav M. Patel; Zhongping Chen
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Paper Abstract

An increased number of integrated optical acoustic intravascular imaging systems have been researched and hold great hope for accurate diagnosing of vulnerable plaques and for guiding atherosclerosis treatment. However, in any intravascular environment, vascular lumen is filled with blood, which is a high-scattering source for optical and high frequency ultrasound signals. Blood must be flushed away to make images clear. To our knowledge, no research has been performed to find the ideal flushing agent that works for both optical and acoustic imaging techniques. We selected three solutions, mannitol, dextran and iohexol, as flushing agents because of their image-enhancing effects and low toxicities. Quantitative testing of these flushing agents was performed in a closed loop circulation model and in vivo on rabbits.

Paper Details

Date Published: 26 February 2015
PDF: 6 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032Z (26 February 2015); doi: 10.1117/12.2074696
Show Author Affiliations
Jiawen Li, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Hataka Minami, Univ. of California, Irvine (United States)
Earl Steward, Univ. of California, Irvine School of Medicine (United States)
Teng Ma, The Univ. of Southern California (United States)
Dilbahar Mohar, Univ. of California, Irvine School of Medicine (United States)
Claire Robertson, Lawrence Berkeley National Lab. (United States)
K. Kirk Shung, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Pranav M. Patel, Univ. of California, Irvine School of Medicine (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong; Justus F. Ilgner; Alfred Nuttal; Claus-Peter Richter; Melissa C. Skala; Mark W. Dewhirst; Bernard Choi; Nikiforos Kollias; Haishan Zeng; Guillermo J. Tearney; Kenton W. Gregory; Laura Marcu; Andreas Mandelis, Editor(s)

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