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Proceedings Paper

En-face imaging of the ellipsoid zone in the retina from optical coherence tomography B-scans
Author(s): T. Holmes; S. Larkin; M. Downing; K. Csaky
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Paper Abstract

It is generally believed that photoreceptor integrity is related to the ellipsoid zone appearance in optical coherence tomography (OCT) B-scans. Algorithms and software were developed for viewing and analyzing the ellipsoid zone. The software performs the following: (a), automated ellipsoid zone isolation in the B-scans, (b), en-face view of the ellipsoid-zone reflectance, (c), alignment and overlay of (b) onto reflectance images of the retina, and (d), alignment and overlay of (c) with microperimetry sensitivity points. Dataset groups were compared from normal and dry age related macular degeneration (DAMD) subjects. Scalar measurements for correlation against condition included the mean and standard deviation of the ellipsoid zone’s reflectance. The imageprocessing techniques for automatically finding the ellipsoid zone are based upon a calculation of optical flow which tracks the edges of laminated structures across an image. Statistical significance was shown in T-tests of these measurements with the population pools separated as normal and DAMD subjects. A display of en-face ellipsoid-zone reflectance shows a clear and recognizable difference between any of the normal and DAMD subjects in that they show generally uniform and nonuniform reflectance, respectively, over the region near the macula. Regions surrounding points of low microperimetry (μP) sensitivity have nonregular and lower levels of ellipsoid-zone reflectance nearby. These findings support the idea that the photoreceptor integrity could be affecting both the ellipsoid-zone reflectance and the sensitivity measurements.

Paper Details

Date Published: 20 March 2015
PDF: 12 pages
Proc. SPIE 9307, Ophthalmic Technologies XXV, 93071O (20 March 2015); doi: 10.1117/12.2074193
Show Author Affiliations
T. Holmes, Lickenbrock Technologies, LLC (United States)
S. Larkin, Lickenbrock Technologies, LLC (United States)
M. Downing, Retina Foundation of the Southwest (United States)
K. Csaky, Retina Foundation of the Southwest (United States)
Univ. of Texas Southwestern Medical Ctr. (United States)
Texas Retina Associates (United States)

Published in SPIE Proceedings Vol. 9307:
Ophthalmic Technologies XXV
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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