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Proceedings Paper

Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer
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Paper Abstract

The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six optical subsystems, two from OCT and four from MFI. The optical subsystems have independent and interrelated design criteria. The endoscope will be tested on realistic tissue models and ex vivo tissue to prove feasibility of future human trials. Ultimately the project aims to provide women the first effective ovarian cancer screening technique.

Paper Details

Date Published: 17 December 2014
PDF: 8 pages
Proc. SPIE 9293, International Optical Design Conference 2014, 92931F (17 December 2014); doi: 10.1117/12.2073824
Show Author Affiliations
Tyler Tate, College of Optical Sciences, The Univ. of Arizona (United States)
Molly Keenan, The Univ. of Arizona (United States)
Elizabeth Swan, College of Optical Sciences, The Univ. of Arizona (United States)
John Black, Glannaventa, Inc. (United States)
Urs Utzinger, College of Optical Sciences, The Univ. of Arizona (United States)
The Univ. of Arizona
Jennifer Barton, College of Optical Sciences, The Univ. of Arizona (United States)
The Univ. of Arizona


Published in SPIE Proceedings Vol. 9293:
International Optical Design Conference 2014
Mariana Figueiro; Scott Lerner; Julius Muschaweck; John Rogers, Editor(s)

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