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Proceedings Paper

Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain
Author(s): Edgar Guevara; Romain Berti; Irène Londono; Ningshi Xie; Pierre Bellec; Frédéric Lesage; G. A. Lodygensky
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Paper Abstract

Periventricular leukomalacia (PVL) is a condition that may cause significant neurodevelopmental handicap in premature newborns. It is characterized by white matter injury, associated with inflammation. This work aimed to assess the impact of inflammation on cerebral oxygen saturation (sO2) using depth-sensitive photoacoustic tomography (PAT). The aspects of PVL were reproduced in a rodent model by injection of lipopolysaccharide (LPS) into the corpus callosum. The results of this exploratory work reveal lower sO2 values in LPS group, as compared to sham controls; showing decreased values in the corpus callosum and in the left cortex, ipsilateral to the injection site. Interhemispherical connectivity was not affected by LPS injection, as shown by functional connectivity analysis. This study supports the use of PAT as a non-invasive tool to assess oxygenation values in vivo in the newborn brain.

Paper Details

Date Published: 25 September 2014
PDF: 6 pages
Proc. SPIE 9288, Photonics North 2014, 92880Q (25 September 2014); doi: 10.1117/12.2073720
Show Author Affiliations
Edgar Guevara, Ecole Polytechnique de Montréal (Canada)
Romain Berti, Ecole Polytechnique de Montréal (Canada)
Montreal Heart Institute (Canada)
Irène Londono, Univ. de Montréal (Canada)
Ningshi Xie, Univ. de Montréal (Canada)
Pierre Bellec, Univ. de Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)
Montreal Heart Institute (Canada)
G. A. Lodygensky, Univ. de Montréal (Canada)

Published in SPIE Proceedings Vol. 9288:
Photonics North 2014
Steve MacLean; David V. Plant, Editor(s)

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