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Proceedings Paper

Cytotoxicity studies of CdSeS/ZnS quantum dots on cell culture in microfluidic system
Author(s): Maja Haczyk; Ilona Grabowska-Jadach; Marcin Drozd; Mariusz Pietrzak; Elżbieta Malinowska; Zbigniew Brzózka
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Paper Abstract

Quantum dots (QDs) semi-conducting nanocrystals have found numerous applications in many fields of science. Nowadays one can observe a growing perspective to use them in biomedicine. Thanks to QDs unique fluorescence properties (narrow emission spectra, high extinction coefficients, high quantum yields, photostability) and possibility to form conjugates with bioactive molecules, they can become a chance for better cancer cells imaging in cancer therapy. Therefore there is a need for better understanding of biological interactions between QDs and cancer cells in vitro. For this purpose we performed cytotoxicity tests of CdSeS/ZnS quantum dots stabilized with mercaptopropionic acid (MPA) ligand, on human lung cancer cell line (A549) in vitro in macro- (96-well plate) and micro-scale (a specially designed and fabricated microfluidic device). The results obtained demonstrated a little extent of cytotoxic effect of selected solutions of QDs to A549 cells.

Paper Details

Date Published: 19 August 2014
PDF: 6 pages
Proc. SPIE 9291, 13th International Scientific Conference on Optical Sensors and Electronic Sensors, 92910L (19 August 2014); doi: 10.1117/12.2073414
Show Author Affiliations
Maja Haczyk, Warsaw Univ. of Technology (Poland)
Ilona Grabowska-Jadach, Warsaw Univ. of Technology (Poland)
Marcin Drozd, Warsaw Univ. of Technology (Poland)
Mariusz Pietrzak, Warsaw Univ. of Technology (Poland)
Elżbieta Malinowska, Warsaw Univ. of Technology (Poland)
Zbigniew Brzózka, Warsaw Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 9291:
13th International Scientific Conference on Optical Sensors and Electronic Sensors
Jacek Golebiowski; Roman Gozdur, Editor(s)

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