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Proceedings Paper

A T1 and DTI fused 3D corpus callosum analysis in pre- vs. post-season contact sports players
Author(s): Yi Lao; Meng Law; Jie Shi; Niharika Gajawelli; Lauren Haas; Yalin Wang; Natasha Leporé
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Paper Abstract

Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. Here, for the first time, we fuse T1 surface-based morphometry and a new DTI analysis on 3D surface representations of the CCs into a single statistical analysis on these subjects. Our new combined method successfully increases detection power in detecting differences between pre- vs. post-season contact sports players. Alterations are found in the ventral genu, isthmus, and splenium of CC. Our findings may inform future health assessments in contact sports players. The new method here is also the first truly multimodal diffusion and T1-weighted analysis of the CC, and may be useful to detect anatomical changes in the corpus callosum in other multimodal datasets.

Paper Details

Date Published: 28 January 2015
PDF: 6 pages
Proc. SPIE 9287, 10th International Symposium on Medical Information Processing and Analysis, 92870O (28 January 2015); doi: 10.1117/12.2072600
Show Author Affiliations
Yi Lao, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)
Meng Law, The Univ. of Southern California (United States)
Jie Shi, Arizona State Univ. (United States)
Niharika Gajawelli, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)
Lauren Haas, The Univ. of Southern California (United States)
Yalin Wang, Arizona State Univ. (United States)
Natasha Leporé, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 9287:
10th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore, Editor(s)

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