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Proceedings Paper

Mueller-matrix imaging of laser autofluorescence of biological tissues
Author(s): L. I. Trifoniuk; A. G. Ushenko; O. V. Dubolazov; A. O. Gritsyuk; A. O. Karachevtsev; M. Sidor
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Paper Abstract

The work consists of investigation results of diagnostic efficiency of a new azimuthally stable Muellermatrix method of analysis of laser autofluorescence coordinate distributions of biological tissues histological sections. A new model of generalized optical anisotropy of biological tissues protein networks is proposed in order to define the processes of laser autofluorescence. The influence of complex mechanisms of both phase anisotropy (linear birefringence and optical activity) and linear (circular) dichroism is taken into account. The interconnections between the azimuthally stable Mueller-matrix elements characterizing laser autofluorescence and different mechanisms of optical anisotropy are determined. The statistic analysis of coordinate distributions of such Mueller-matrix rotation invariants is proposed. Thereupon the quantitative criteria (statistic moments of the 1st to the 4th order) of differentiation of histological sections of myometrium – group 1 (fibromyoma) and group 2 (adenocarcinoma) are estimated.

Paper Details

Date Published: 20 February 2015
PDF: 11 pages
Proc. SPIE 9258, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VII, 925815 (20 February 2015); doi: 10.1117/12.2072264
Show Author Affiliations
L. I. Trifoniuk, Bukovinian State Medical Univ. (Ukraine)
A. G. Ushenko, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
O. V. Dubolazov, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
A. O. Gritsyuk, Bukovinian State Medical Univ. (Ukraine)
A. O. Karachevtsev, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
M. Sidor, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)


Published in SPIE Proceedings Vol. 9258:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VII
Ionica Cristea; Marian Vladescu; Razvan Tamas, Editor(s)

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