Share Email Print

Proceedings Paper

Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy
Author(s): Yanyan Fang; Xiaopu Wang; Qianli Zou; Yuxia Zhao; Feipeng Wu
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

A series of amphiphilic benzylidene cycloalkanes ketone photosensitizers C1-C4 with or without folate receptor-targeted agent were designed and synthesized. Their photophysical properties and in vitro photodynamic therapy (PDT) effects were studied. The results showed that all compounds exhibited appropriate lipid-water partition coefficients and high reactive oxygen yields. The introduction of the folate receptor-targeted agent had no obvious influence on the basic photophysical & photochemical properties of C2 and C4 compared to those of their corresponding prototype compounds (C1 and C3). In vitro studies were carried out using MCF-7 cells (FR+), Hela cells (FR+) and A549 cells (FR-), which represented different levels of folate receptor (FR) expression. All of C1-C4 showed low dark toxicity and superior PDT effects compared with the clinical drug PSD-007 (a mixture of porphyrins). What’s more, folate receptor-targeted photosensitizers (C2 and C4) achieved higher accumulation and more excellent PDT effects in MCF-7 cells (FR+) and Hela cells (FR+) than photosensitizers (C1 and C3) without folate receptor-targeted agent and PSD-007. The photocytotoxicity of these photosensitizers showed no obvious differences in A549 cells (FR-).

Paper Details

Date Published: 18 November 2014
PDF: 7 pages
Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92680O (18 November 2014); doi: 10.1117/12.2071756
Show Author Affiliations
Yanyan Fang, Technical Institute of Physics and Chemistry (China)
Xiaopu Wang, Technical Institute of Physics and Chemistry (China)
Univ. of Chinese Academy of Sciences (China)
Qianli Zou, Technical Institute of Physics and Chemistry (China)
Yuxia Zhao, Technical Institute of Physics and Chemistry (China)
Feipeng Wu, Technical Institute of Physics and Chemistry (China)

Published in SPIE Proceedings Vol. 9268:
Optics in Health Care and Biomedical Optics VI
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

© SPIE. Terms of Use
Back to Top