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Proceedings Paper

In-vivo monitoring rat skin wound healing using nonlinear optical microscopy
Author(s): Jing Chen; Chungen Guo; Fan Zhang; Yahao Xu; Xiaoqin Zhu; Shuyuan Xiong; Jianxin Chen
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Paper Abstract

Nonlinear optical microscopy (NLOM) was employed for imaging and evaluating the wound healing process on rat skin in vivo. From the high-resolution nonlinear optical images, the morphology and distribution of specific biological markers in cutaneous wound healing such as fibrin clot, collagens, blood capillaries, and hairs were clearly observed at 1, 5 and 14 days post injury. We found that the disordered collagen in the fibrin clot at day 1 was replaced by regenerative collagen at day 5. By day 14, the thick collagen with well-network appeared at the original margin of the wound. These findings suggested that NLOM is ideal for noninvasively monitoring the progress of wound healing in vivo.

Paper Details

Date Published: 20 November 2014
PDF: 5 pages
Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 926820 (20 November 2014); doi: 10.1117/12.2071547
Show Author Affiliations
Jing Chen, Fujian Normal Univ. (China)
Chungen Guo, Affiliated First Hospital Fujian Medical Univ. (China)
Fan Zhang, Affiliated First Hospital Fujian Medical Univ. (China)
Yahao Xu, Fujian Normal Univ. (China)
Xiaoqin Zhu, Fujian Normal Univ. (China)
Shuyuan Xiong, Affiliated First Hospital Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 9268:
Optics in Health Care and Biomedical Optics VI
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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