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Proceedings Paper

Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2 um diode laser
Author(s): Mingguo Sun; Hongliang Ma; Zhensong Cao; Kun Liu; Guishi Wang; Lei Wang; Qiang Liu; Xiaoming Gao
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Paper Abstract

A laser spectrometer based on a distributed-feedback semiconductor diode laser at 2 μm is developed to measure the changes of 13CO2/12CO2 isotope ratio in exhaled breath sample with the CO2 concentration of ~4%. It is characterized by a simplified optical layout, in which a single detector and associated electronics are used to probe CO2 spectrum. The cell has 10 cm long base length with 26.4 m optical path length in total and 330 cm3 volume. The cell pressure and temperature are controlled at 50 Torr and 28℃, respectively. The best 13δ precision of 0.06‰ was achieved by using wavelet denoising and Kalman filter.

Paper Details

Date Published: 20 November 2014
PDF: 7 pages
Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681O (20 November 2014); doi: 10.1117/12.2071221
Show Author Affiliations
Mingguo Sun, Key Lab. of Atmospheric Composition and Optical Radiation (China)
Anhui Institute of Optics and Fine Mechanics (China)
Hongliang Ma, Key Lab. of Atmospheric Composition and Optical Radiation (China)
Zhensong Cao, Key Lab. of Atmospheric Composition and Optical Radiation (China)
Kun Liu, Anhui Institute of Optics and Fine Mechanics (China)
Guishi Wang, Anhui Institute of Optics and Fine Mechanics (China)
Lei Wang, Anhui Institute of Optics and Fine Mechanics (China)
Qiang Liu, Chinese Academy of Sciences (China)
Xiaoming Gao, Anhui Institute of Optics and Fine Mechanics (China)


Published in SPIE Proceedings Vol. 9268:
Optics in Health Care and Biomedical Optics VI
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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