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Proceedings Paper

Effect on influenza hemagglutinin protein binding with neutralizing antibody using terahertz spectroscopy technology
Author(s): Yiwen Sun; Junlan Zhong; Jian Zuo; Cunlin Zhang
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Paper Abstract

Terahertz spectroscopy is sensitive to probe several aspects of biological systems. We have reported the terahertz dielectric spectrum is able to identify the type of the charges in the hydrogen-bonded antibodies’ networks in our previous work. Recently we demonstrate a highly sensitive THz-TDS method to monitor binding interaction of influenza hemagglutinin (HA) against its target antibody F10. The terahertz dielectric properties of HA was strongly affected by the presence of a specific antibody. Protein solution concentration or even molecular binding interaction can also affect the terahertz signal. This enables us to detect the specificity and sensitivity of antibody-antigen binding under THz radiation.

Paper Details

Date Published: 11 November 2014
PDF: 6 pages
Proc. SPIE 9275, Infrared, Millimeter-Wave, and Terahertz Technologies III, 927505 (11 November 2014); doi: 10.1117/12.2071098
Show Author Affiliations
Yiwen Sun, Shenzhen Univ. (China)
Junlan Zhong, Shenzhen Univ. (China)
Jian Zuo, Capital Normal Univ. (China)
Cunlin Zhang, Capital Normal Univ. (China)

Published in SPIE Proceedings Vol. 9275:
Infrared, Millimeter-Wave, and Terahertz Technologies III
Cunlin Zhang; Xi-Cheng Zhang; Masahiko Tani, Editor(s)

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