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Proceedings Paper

NIR rapid assessments of Chinese material medica: simultaneous determination of three major active components of licorice
Author(s): Zhisheng Wu; Xiangzhen Zhou; Fulai Yu; Xinyuan Shi; Wenquan Wang; Yanjiang Qiao
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Paper Abstract

Objective: A rapid and nondestructive method was used to quantitatively predict the content of three main active components (glycyrrhizin, liquiritin and isoliquiritin) in licorice by near infrared spectroscopy (NIRS). Methods: Diffuse reflectance spectra of licorice powder were obtained, the contents of glycyrrhizin, liquiritin and isoliquiritin were analyzed simultaneously by high-performance liquid chromatography (HPLC). The partial least squares (PLS) regression algorithm was used to establish the quantitative models. Several pretreatments such as multiplicative scatter correction (MSC), first derivative, second derivative and Savitzky-Golay (SG) smoothing were utilized to correct the scattering effect and eliminate the baseline shift in all spectra. The calibration equations produced the highest determination of coefficient values (R2), the lowest root mean square error of calibration (RMSEC) and the lowest root mean square error of prediction (RMSEP) were used for the determination of glycyrrhizin, liquiritin and isoliquiritin. Results: The R2 of glycyrrhizin, liquiritin and isoliquiritin were 0.999, 0.996 and 0.999, respectively. The RMSEC of glycyrrhizin, liquiritin and isoliquiritin were 1.14 mg/g, 0.77 mg/g and 0.068 mg/g respectively. The RMSEP of glycyrrhizin, liquiritin and isoliquiritin were 4.92 mg/g, 2.06 mg/g and 0.35 mg/g respectively. Conclusions: The results indicated that the NIRS method could be used for the rapid assessment of licorice.

Paper Details

Date Published: 20 November 2014
PDF: 7 pages
Proc. SPIE 9300, International Symposium on Optoelectronic Technology and Application 2014: Infrared Technology and Applications, 93000R (20 November 2014); doi: 10.1117/12.2071029
Show Author Affiliations
Zhisheng Wu, Beijing Univ. of Chinese Medicine (China)
Xiangzhen Zhou, Beijing Univ. of Chinese Medicine (China)
Hainan Medical College (China)
Fulai Yu, Beijing Univ. of Chinese Medicine (China)
Chinese Academy of Tropical Agricultural Sciences (China)
Xinyuan Shi, Beijing Univ. of Chinese Medicine (China)
Wenquan Wang, Beijing Univ. of Chinese Medicine (China)
Chinese Academy of Medical Science (China)
Peking Union Medical College (Colombia)
Yanjiang Qiao, Beijing Univ. of Chinese Medicine (China)


Published in SPIE Proceedings Vol. 9300:
International Symposium on Optoelectronic Technology and Application 2014: Infrared Technology and Applications
Mircea Guina; Haimei Gong; Zhichuan Niu; Jin Lu, Editor(s)

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